Author's response to reviews Title: Genes Associated with MUC5AC Expression in Small Airway Epithelium of Human Smokers and Non-smokers Authors:
نویسندگان
چکیده
Guoqing Wang ([email protected]) Zhibo Xu ([email protected]) Rui Wang ([email protected]) Mohammed Al-Hijji ([email protected]) Jacqueline Salit ([email protected]) Yael Strulovici-Barel ([email protected]) Ann Tilley ([email protected]) Jason Mezey ([email protected]) Ronald Crystal ([email protected])
منابع مشابه
Expression of ErbB receptors and mucins in the airways of long term current smokers.
BACKGROUND Airway epithelial goblet cell hyperplasia is known to occur in chronic smokers. Although the epidermal growth factor receptor has been implicated in this process, neither ErbB receptor expression nor the mucosecretory phenotype of the epithelium have been characterised in current smokers. METHODS Bronchial biopsies obtained from non-smokers (n = 10) and current smokers, with or wit...
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Background: Airway epithelial goblet cell hyperplasia is known to occur in chronic smokers. Although the epidermal growth factor receptor has been implicated in this process, neither ErbB receptor expression nor the mucosecretory phenotype of the epithelium have been characterised in current smokers. Methods: Bronchial biopsies obtained from non-smokers (n = 10) and current smokers, with or wit...
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BACKGROUND The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA. Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overproduction, we hypothesized that cigarette smoking, another disorder associated with increased mucus pr...
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Lectins are innate immune defense proteins that recognize bacterial cell wall components. Based on the knowledge that cigarette smoking is associated with an increased risk of infections, we hypothesized that cigarette smoking may modulate the expression of lectin genes in airway epithelium. Affymetrix microarrays were used to survey the expression of lectin genes in large airway epithelium fro...
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